Does a "working" immune system lead to fatigue?

Such as if a character have a certain disease or infection, does this exact fatigue within the soul?

Answers:
I believe that the answer is YES and the idea is because our body is really sophisicated and know how to alleviate itself, but singular if we listen to the signals.

The immune system requirements us to rest surrounded by direct to do it's opportunity, so we be aware of tired, that's the body's signal recitation us what it requirements. When we listen our body can restore to health, when we rebuff the signal our body must find other funds to signal.import, a more serious infection may surface.
In a style yes, because the working immune system uses force to net the types of white cell needed to collide infections and foreign invaders. People near cancer whose immune systems don't work ably, recurrently don't realize they are unwell because they don't get the impression below par or tired.
People next to autoimmune diseases(overactive immune system)
tons time suffer from fatigue due to here disorder.

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