Answers: It is in interesting interrogate and is tough to answer without knowing specifically what disease I am looking to treat. But I am going to assume you come into my ER, looking septic, and I am of late gonna give you broad spectrum antibiotics until I can culture you and de-escalate from nearby. I learn along the approach you have chronic liver disease. I get the impression that the use of cefepime and vancomycin would still be warranted because both are renally excreted. Cefepime is cleared primarily by urinary excretion (85%). Vancomycin is cleared primarily by urinary excretion (75%). This may fluctuate in your nouns, but around here we get a do amount of community acquired MRSA infections.
A tremendously generic answer that can change due to frequent other factors, especially.
Also, you could make the addition of metronidazole for anaerobe coverage. Metronidazole — Excretion: Renal (60-80%)