for pathophysiology class
Answers:
Methotrexate inhibits "dihydrofolic acerbic reductase". Dihydrofolates must be reduced to tetrahydrofolates by this enzyme since they can be utilized as carrier of one-carbon groups contained by the synthesis of p.r.n. nucleotides and thymidylate. Therefore, methotrexate interferes beside DNA synthesis, repair, and cellular replication.
In cancer, they are prompt growing cell and this process is taking place more frequently than within regular tissue. Interference near this process slows down the reproduction of modern cell fairly than interfereing next to existing ready cancer cell. Skin, tresses, blood, and soft tissue are also hurried growing cell and replace themselves on a 28 daytime cycle. This is why using chemotherapeutic items that interfere next to cell growth affect them commonly too.
1) How it renders cell non-viable: Methotrexate act during DNA and RNA synthesis, and is cytotoxic during the S-phase of the cell cycle. Since cancer cell divide more fast, it have a greater effect on them.
2) Specific enzyme pathway: folate synthesis pathway
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Answers:
Methotrexate inhibits "dihydrofolic acerbic reductase". Dihydrofolates must be reduced to tetrahydrofolates by this enzyme since they can be utilized as carrier of one-carbon groups contained by the synthesis of p.r.n. nucleotides and thymidylate. Therefore, methotrexate interferes beside DNA synthesis, repair, and cellular replication.
In cancer, they are prompt growing cell and this process is taking place more frequently than within regular tissue. Interference near this process slows down the reproduction of modern cell fairly than interfereing next to existing ready cancer cell. Skin, tresses, blood, and soft tissue are also hurried growing cell and replace themselves on a 28 daytime cycle. This is why using chemotherapeutic items that interfere next to cell growth affect them commonly too.
1) How it renders cell non-viable: Methotrexate act during DNA and RNA synthesis, and is cytotoxic during the S-phase of the cell cycle. Since cancer cell divide more fast, it have a greater effect on them.
2) Specific enzyme pathway: folate synthesis pathway